Download Cell Polarity and Subcellular RNA Localization (Results and by Dietmar Richter PDF

By Dietmar Richter

Selective cytoplasmic organelle and protein concentrating on has lengthy been suggestion to represent the only real determinant of telephone polarity and complexity. This view has been replaced, although, by means of the invention of differential subcellular RNA distribution styles. over the last decade it has develop into transparent that selective mRNA sorting and translation contributes to an accumulation of cognate proteins at discrete mobile websites. during this e-book, a variety of structures are mentioned (e.g. Xenopus oocytes, mammalian mind, invertebrate fearful process) by way of RNA trafficking, RNA-targeting sequences (cis-elements) and RNA-transporting proteins (trans-factors), activity-dependent translational rules and the importance of the cytoskeleton for neuronal functionality and plasticity. It additionally discusses nucleocytoplasmic export of mRNA and viral RNA as one other instance of subcellular RNA kinesis.

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